By Donata Vercelli MD (auth.), Judah A. Denburg MD, FRCP(C) (eds.)
In hypersensitivity and Allergic ailments: the hot Mechanisms and Therapeutics, a exotic foreign panel of researchers and clinicians evaluation the most recent findings at the mobile and molecular foundations of allergic illnesses, rather these of the airway, dermis, and bowel. the foremost subject matters handled span the variety from epidemiology and the mechanisms of irritation, to signaling in pathogenesis and allergies. each one contributor treats the pathophysiology of allergic reaction in a variety of organ-based ailments and syndromes, emphasizing very important new findings from mobile and molecular biology that remove darkness from those illnesses, but in addition display very important leads for the improvement of novel medications and healing concepts.
allergic reaction and Allergic ailments: the hot Mechanisms and Therapeutics highlights the interface among uncomplicated and medical technology in allergic affliction. Its up to date, clinically appropriate procedure constitutes the hot typical wisdom base in medical immunology and hypersensitivity, not just for experts, but in addition for internists, for scientists learning the mobile and molecular biology of irritation and immunity, and for researchers curious about drug discovery and therapeutics. Authoritative and well timed, hypersensitivity and Allergic illnesses is obviously the state-of-the-art crucial new source for all physicians and investigators looking a deeper figuring out of allergic reaction in either its uncomplicated and scientific features.
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Additional resources for Allergy and Allergic Diseases: The New Mechanisms and Therapeutics
IL-12 also inhibited IL-4- and IL-13-induced IgE production by sJl+, CDlO+, and CD19+ immature fetal B-cells cultured in the presence of activated CD4+ T-cells (94). , in the presence of anti-CD40 MAbs. In fact, IL-12 has stimulatory effects on purified B-cells, and it enhances B-cell proliferation and differentiation of activated B-cells in vitro. Furthermore, IL-12 did not affect germline e transcription by purified human B-cells. IL-12 also inhibits IgE synthesis in mice in vivo. The primary IgE responses to N.
Anti-CD40 MAbs, which are ineffective when tested alone, strongly synergize with both IL-4 and IL-13 in inducing germline £ RNA synthesis in normal human B-cells and immature B-cells (74,138). In addition, combinations of anti-CD40 MAbs and IL-4 and IL-13 induce productive £ transcription and IgE synthesis by these cells. Both IL-4 and IL-13 also induced germline £ transcription in human immature B cells derived from fetal spleen or bone marrow (BM) (138). C pre-B cells (138). Similarly, in contrast to IL-4, IL-13 did not affect the expression of CD23, CD40, or HLA-DR on pre-B-cells, suggesting differential effects ofIL-4 and IL-13 on early fetal B cells (94).
YI24D, binds with high affinity to the IL-4R a-chain without significant receptor activation (71 ,217). YI24D blocks the biological activities of both IL-4 and IL-13. YI24D inhibited in a dose-dependent manner IgG4 and IgE synthesis induced by optimal concentrations ofIL-4 or IL-13 in vitro (75). YI24D was added at 20-50-fold excess as com- Chapter 2 / Cytokines and IgE Regulation 29 pared to IL-4 or IL-13. Y124D effectively inhibited IL-4- and IL-13induced B-cell proliferation and germline E transcription (214).
Allergy and Allergic Diseases: The New Mechanisms and Therapeutics by Donata Vercelli MD (auth.), Judah A. Denburg MD, FRCP(C) (eds.)